Granted, it may be tough to tackle your kids' rooms, but you don't have to live with clutter in the rest of your house. Clearing clutter isn't complicated if you follow an organizing principle. Gather four good-sized cardboard boxes and go room by room. Fill them as follows:
Throw away anything that you don't need or want, and that no one else does, either. If you have things that are damaged or broken, and that can't be repaired, toss them.
Give away, donate, or sell anything that you don't absolutely love, but which has some value. If all these objects are doing is taking up space in your home, let someone have them who will really enjoy them.
Put in storage things that you do not use or need on a regular basis, but which you can't bear to part with. Perhaps it's your grandmother's knick-knacks, or an old tennis trophy. Store these items in labeled boxes, so you can easily find them again.
Keep any essentials that you need to have available. Be honest with yourself about this, and make sure these items have a place of their own, without creating clutter. If they don't, come up with an attractive storage solution – meantime, leave them in the box!